What is plasma?

Technology & Published Data

Plasma is one of the four fundamental states of matter, the others being solid, liquid, and gas. A plasma can be created by heating a gas or subjecting it to a strong electromagnetic field. Plasma is made up of electrons, ions, and neutral species. Low temperature plasmas have the ions and neutrals at a much lower temperature, whereas electrons are much "hotter". The overall temperature of the plasma is can be close to body temperature.

Plasma are commonly used in many industries to modify and/or clean surfaces for custom applications ranging from the medical, automotive, food, and electronics industries. More recently, the biological and medical applications of plasmas have witnessed a great interest from the plasma and medical research communities. This is due to promising applications in medical research such as electrosurgery, tissue engineering, surface modification of biocompatible materials, and the sterilization of heat sensitive materials and instruments.

Cold Plasma Technology

Provide cutting-edge dental care with the latest innovation in surface engineering

Dental Restoration


The bonding strength of the composite restoration to dentin can be increased up to 64% after 30 seconds of Plasma Brush treatment.

Oral Disinfection


Plasma Brush treatment of S. mutans results in a 99.9999% reduction within 15 seconds.

Teeth Whitening


Plasma treatment reduces in-office teeth whitening chair time from a hour to 30 minutes.


Plasma Brush applications are waiting for FDA and CE clearance

Clinical Trial

ClinicalTrials.gov Identifier: NCT01529606

A clinical trial was completed in 2014 with total enrollment of 102 patients.

The objective of the clinical trial portion of the study is to compare the longevity and durability of dental composite restorations created using the plasma brush, to that of the standard care in dentistry for treating dental cavities, and effects on caries prevention.

For patients in standard treatment group, they will receive composite resin restoration for all decayed teeth and standard preventive treatment (cleaning and fluoride varnish application) at baseline. For patients in plasma treatment group, they will receive plasma treatment after cavity preparation, composite resin restoration, standard preventive treatment followed by plasma treatment for non-carious teeth.

Published Data

  1. Non-thermal Plasma Enhanced Bonding of Resin Cement to Zirconia Ceramic, Tianshuang Liu, Liang Hong, Timothy Hottel, Xiaoqing Dong, Qingsong Yu, Meng Chen, Clinical Plasma Medicine, 4 (2), 50-55, 2016.
  2. Improving Bond Strength of Ground and Intact Enamel to Mild Self-etch Adhesive by Plasma Treatment, Mingming Gu, Qingsong Yu, Jingwen Tan, Hao Li, Meng Chen, Yong Wang, Xiaoqing Dong, Clinical Plasma Medicine, 4 (1), 29-33, 2016.
  3. Disinfection of Streptococcus mutans Biofilm by a Non-Thermal Atmospheric Plasma Brush, Qing Hong, Xiaoqing Dong, Meng Chen, Yuanxi Xu, Hongmin Sun, Liang Hong, Qingsong Yu, Japanese Journal of Applied Physics, 55, 07LG02 (1-6), 2016.
  4. Plasma Treatment of Dentin Surfaces for Improving Self-etching Adhesive/dentin Interface Bonding, Xiaoqing Dong, Hao Li, Meng Chen, Yong Wang, Qingsong Yu, Clinical Plasma Medicine, 3 (1), 10-16, 2015.
  5. Plasma Deactivation of Oral Bacteria Seeded on Hydroxyapatite Disks as Tooth Enamel Analogue, Adam Blumhagen, Prashant Singh, Azlin Mustapha, Meng Chen, Yong Wang, Qingsong Yu, American Journal of Dentistry, 27 (2), 87-90, 2014.
  6. Antimicrobial Effects of Non-thermal Atmospheric Plasma as a Novel Root Canal Disinfectant, Mariam Habib, Timothy L. Hottel, Liang Hong, Clinical Plasma Medicine, 2, 17–21, 2014.
  7. A Mechanistic Study of Plasma Treatment Effects on Demineralized Dentin Surfaces for Improved Adhesive/dentin Interface Bonding, Xiaoqing Dong, Meng Chen, Yong Wang, Qingsong Yu, Clinical Plasma Medicine, 2 (1), 11-16, 2014.
  8. Evaluation of Plasma Treatment Effects on Improving Adhesive/dentin Bonding by Using the Same Tooth Controls and Varying Cross-sectional Surface Areas, Xiaoqing Dong, Andy Charles Ritts, Corey Staller, Qingsong Yu, Meng Chen, Yong Wang, European Journal of Oral Science, 121, 355-362, 2013.
  9. Non-thermal Atmospheric Plasma Treatment for Deactivation of Oral Bacteria and Improvement of Dental Composite Restoration, Q.S. Yu, H. Li, A.C. Ritts, B. Yang, M. Chen, L. Hong, C. Xu, X. Yao, Y. Wang, in NATO Science for Peace and Security Series – A: Chemistry and Biology, Edited by Zdenko Machala and Yuri Akishev, ISBN 978-94-007--2851-6, Springer, 2012, 215-228.
  10. Oral Bacterial Deactivation Using a Low-Temperature Atmospheric Argon Plasma Brush, Bo Yang, Jierong Chen, Qingsong Yu, Hao Li, Mengshi Lin, Azlin Mustapha, Liang Hong, Yong Wang, Journal of Dentistry, 39, 48 – 56, 2011.
  11. Dentin Surface Treatment using a Non-thermal Argon Plasma Brush for Interfacial Bonding Improvement in Composite Restoration, Andrew Charles Ritts, Hao Li, Qingsong Yu, Changqi Xu, Xiaomei Yao, Liang Hong, Yong Wang, European Journal of Oral Science, 118, 510 – 516, 2010.

Copyright © 2017 Nanova, Inc. / All rights reserved.